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KMID : 0811720080120030125
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Korean Journal of Physiology & Pharmacology
2008 Volume.12 No. 3 p.125 ~ p.128
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Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population
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Han Dong-Hee
Choi Bong-Keun
Kim Keon-Sik
Chung Joo-Ho
Kim Su-Kang
Kang Sung-Wook
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Abstract
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The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of matrix metallopeptidase 2 (MMP2) are associated with obesity. MMP2 is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. To identify the relationship between polymorphisms of MMP2 and overweight/obese, we genotyped 5 SNPs (rs17242319, rs1053605, rs243849, rs2287074, and rs10775332) of the coding region of MMP2 using the Golden Gate assay on an Illumina BeadStation 500 GX. One hundred and forty two overweight/
obese (BMI ≥23) and 145 normal (BMI 18 to ＜23) subjects were analyzed. SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used for the analysis of genetic data. A linkage disequilibrium (LD) block was discovered among the 5 SNPs selected, including rs17242319, rs1053605, rs243849, and rs2287074. Of the 5 polymorphisms, 2 synonymous SNPs [rs17242319 (Gly226Gly) and rs10775332 (Phe602Phe)] were found significant associations with overweight/obese. Recently, rs1132896 replaced rs17242319 as a new number (SNP database, BUILD 129). In haplotype
analysis using Haploview, a haplotype (haplotype: CCCA) containing a meaningful polymorphism (rs17242319) was found to be significantly different. The results suggest that MMP2 may be associated with overweight/obese in Korean population.
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KEYWORD
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Body mass index, Linkage disequilibrium, Matrix metallopeptidase 2, Obesity, Single nucleotide polymorphism
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